A woman’s risk of breast cancer is affected by her genetic make up. Some bits of the normal genetic material (DNA) differs between one person and another: they are known as single nucleotide polymorphisms or SNPs. Different combinations of these SNPs are associated with different levels of risk. New SNPs have been recently identified as being associated with a greater breast cancer risk, and we have just issued a scientific publication now listing a total of 313 SNPs that contribute to predict individual breast cancer risk. In the MyPeBS study, all 313 SNPs will be genotyped on a customized DNA chip and the result will be included in the form of a PRS (Polygenic risk score) in the breast cancer risk score that will be estimated for each woman randomized in the risk-based arm.
Mavaddat et al., Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes, The American Journal of Human Genetics (2019)